Eligibility

Inclusion criteria:

• Patients with UC or IBD-U refractory to medical therapy or with dysplasia
• Patients undergoing a 1-, 2-stage, 3-stage approach
• Between 18 years old and 60 years old.
• Speak English and/or primary language of recruiting center.
• Provide informed consent

Exclusion criteria:

• Patients with familial adenomatous polyposis (FAP);
• Patients with contraindications for laparoscopic surgery including previous laparotomy, toxic megacolon and chronic obstructive pulmonary disease (COPD) Gold III or higher;
• Patients still taking steroids at the time of proctectomy and IPAA construction. A wash-out period of 8 weeks will be considered for all treatments before performing the pouch construction.
• Patients with confirmed or suspected rectal cancer;
• Patients with primary sclerosing cholangitis (PSC)
• Patients needing a hand-sewn anastomosis;
• Redo-pouch surgery
• Pregnancy and lactation (tested by a urinary pregnancy test)
• Patients undergoing an urgent or emergent proctocolectomy. Those patients are still eligible if they undergo a subtotal colectomy first and a completion proctectomy in a second stage.